Bezmiâlem Vakıf Üniversitesi
Akademik Veri Yönetim Sistemi
Yayınlar & Eserler
SCI,SSCI,AHCI İNDEKSLERİNE GİREN DERGİLERDE YAYINLANAN MAKALELER
Demir-Yazici K., Bua S., Akgunes N.M., Akdemir A., Supuran C.T., Güzel-Akdemir Ö., "Indole-Based Hydrazones Containing A Sulfonamide Moiety as Selective Inhibitors of Tumor-Associated Human Carbonic Anhydrase Isoforms IX and XII", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol.20, 2019
Akdemir A., Angeli A., Göktaş F., Eraslan E.P., Karalı N., Supuran C., "Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida ß-carbonic anhydrase enzyme.", JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.34, pp.528-531, 2019
Ammazzalorso A., Carradori S., Angeli A., Akdemir A., De F.B., Fantacuzzi M., et al., "Fibrate-based N-acylsulphonamides targeting carbonic anhydrases: synthesis, biochemical evaluation, and docking studies.", JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.34, pp.1051-1061, 2019
Gultekin E., Kolcuoglu Y., Akdemir A., Sirin Y., Bektas H., Bekircan O., "A Study On Synthesis, Biological Activities and Molecular Modelling of Some Novel Trisubstituted 1,2,4-Triazole Derivatives", CHEMISTRYSELECT, vol.3, pp.8813-8818, 2018
Ozcan-Sezer S., Ince E., Akdemir A., Ceylan Ö., Suzen S., Gurer-Orhan H., "Aromatase inhibition by 2-methyl indole hydrazone derivatives evaluated via molecular docking and in vitro activity studies.", XENOBIOTICA, vol.-, pp.1-8, 2018
Güzel-Akdemir Ö., Angeli A., Demir K., Supuran C., Akdemir A., "Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors.", JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.33, pp.1299-1308, 2018
Turgut G., Doyduk D., Yıldırır Y., Yavuz S., Akdemir A., Dişli A., et al., "Computer design, synthesis, and bioactivity analyses of drugs like fingolimod used in the treatment of multiple sclerosis.", BİOORGANİC & MEDİCİNAL CHEMİSTRY, vol.25, pp.483-495, 2017
Karalı N., Akdemir A., Göktaş F., Eraslan E.P., Angeli A., Kızılırmak M., et al., "Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases.", BİOORGANİC & MEDİCİNAL CHEMİSTRY, vol.25, pp.3714-3718, 2017
Yavuz S., Cetin A., Akdemir A., Doyduk D., Disli A., Celik Turgut G., et al., "Synthesis and Functional Investigations of Computer Designed Novel Cladribine-Like Compounds for the Treatment of Multiple Sclerosis", ARCHIV DER PHARMAZIE, vol.350, 2017
Mollica A., Macedonio G., Stefanucci A., Carradori S., Akdemir A., Angeli A., et al., "Five- and Six-Membered Nitrogen-Containing Compounds as Selective Carbonic Anhydrase Activators", MOLECULES, vol.22, 2017
D'Ascenzio M., Guglielmi P., Carradori S., Secci D., Florio R., Mollica A., et al., "Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms.", JOURNAL OF ENZYME INHİBİTİON AND MEDİCİNAL CHEMİSTRY, vol.32, pp.51-59, 2017
Çulhaoglu B., Akdemir A., "Target Recognition Molecules and Molecular Modeling Studies", CURRENT TOPİCS IN MEDİCİNAL CHEMİSTRY, vol.17, pp.1580-1587, 2017
De M.C., Carradori S., Bizzarri B., Bolasco A., Caprara F., Mollica A., et al., "Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives.", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.107, pp.82-96, 2016
Carradori S., Secci D., De M.C., Mollica A., Ceruso M., Akdemir A., et al., "A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms.", BIOORGANIC & MEDICINAL CHEMISTRY, vol.24, pp.1095-105, 2016
Richichi B., Baldoneschi V., Burgalassi S., Fragai M., Vullo D., Akdemir A., et al., "A Divalent PAMAM-Based Matrix Metalloproteinase/Carbonic Anhydrase Inhibitor for the Treatment of Dry Eye Syndrome.", CHEMISTRY-A EUROPEAN JOURNAL, vol.22, pp.1714-21, 2016
Akdemir A., Güzel-Akdemir Ö., Karalı N., Supuran C., "Isatin analogs as novel inhibitors of Candida spp. ß-carbonic anhydrase enzymes.", BIOORGANIC & MEDICINAL CHEMISTRY, vol.24, pp.1648-52, 2016
Bozdag M., Carta F., Vullo D., Akdemir A., Isik S., Lanzi C., et al., "Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action.", BIOORGANIC & MEDICINAL CHEMISTRY, vol.23, pp.2368-76, 2015
Güzel-Akdemir Ö., Akdemir A., Karalı N., Supuran C., "Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII.", ORGANIC & BIOMOLECULAR CHEMISTRY, vol.13, pp.6493-9, 2015
Mollica A., Costante R., Akdemir A., Carradori S., Stefanucci A., Macedonio G., et al., "Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies.", BIOORGANIC & MEDICINAL CHEMISTRY, vol.23, pp.5311-8, 2015
Carradori S., Mollica A., Ceruso M., D'Ascenzio M., De M.C., Chimenti P., et al., "New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: biological evaluation and molecular modelling studies.", BIOORGANIC & MEDICINAL CHEMISTRY, vol.23, pp.2975-81, 2015
Akdemir A., De M.C., Carradori S., Supuran C., "Computational investigation of the selectivity of salen and tetrahydrosalen compounds towards the tumor-associated hCA XII isozyme.", JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.30, pp.114-8, 2015
D'Ascenzio M., Carradori S., Secci D., Vullo D., Ceruso M., Akdemir A., et al., "Selective inhibition of human carbonic anhydrases by novel amide derivatives of probenecid: synthesis, biological evaluation and molecular modelling studies.", BIOORGANIC & MEDICINAL CHEMISTRY, vol.22, pp.3982-8, 2014
Güzel-Akdemir Ö., Akdemir A., Pan P., Vermelho A., Parkkila S., Scozzafava A., et al., "A class of sulfonamides with strong inhibitory action against the ?-carbonic anhydrase from Trypanosoma cruzi.", JOURNAL OF MEDICINAL CHEMISTRY, vol.56, pp.5773-81, 2013
Akdemir A., Vullo D., De L.V., Scozzafava A., Carginale V., Rossi M., et al., "The extremo-?-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol.23, pp.1087-90, 2013
Güzel-Akdemir Ö., Akdemir A., Isik S., Vullo D., Supuran C., "o-Benzenedisulfonimido-sulfonamides are potent inhibitors of the tumor-associated carbonic anhydrase isoforms CA IX and CA XII.", BIOORGANIC & MEDICINAL CHEMISTRY, vol.21, pp.1386-91, 2013
Akdemir A., Güzel-Akdemir Ö., Scozzafava A., Capasso C., Supuran C., "Inhibition of tumor-associated human carbonic anhydrase isozymes IX and XII by a new class of substituted-phenylacetamido aromatic sulfonamides.", BIOORGANIC & MEDICINAL CHEMISTRY, vol.21, pp.5228-32, 2013
Carta F., Akdemir A., Scozzafava A., Masini E., Supuran C., "Xanthates and trithiocarbonates strongly inhibit carbonic anhydrases and show antiglaucoma effects in vivo.", JOURNAL OF MEDICINAL CHEMISTRY, vol.56, pp.4691-700, 2013
Akdemir A., Edink E., Thompson A., Lummis S., Kooistra A., De G.C., et al., "Identification of novel ?7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric ?7 receptor ligand binding domain.", BIOORGANIC & MEDICINAL CHEMISTRY, vol.20, pp.5992-6002, 2012
Edink E., Akdemir A., Jansen C., Van E.R., Zuiderveld O., De K.F., et al., "Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol.22, pp.1448-54, 2012
Akdemir A., Rucktooa P., Jongejan A., Elk R., Bertrand S., Sixma T., et al., "Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors.", BIOORGANIC CHEMISTRY, vol.19, pp.6107-19, 2011
Edink E., Rucktooa P., Retra K., Akdemir A., Nahar T., Zuiderveld O., et al., "Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol.133, pp.5363-71, 2011
Ulens C., Akdemir A., Jongejan A., Van E.R., Bertrand S., Perrakis A., et al., "Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis.", JOURNAL OF MEDICINAL CHEMISTRY, vol.52, pp.2372-83, 2009
Bruysters M., Jongejan A., Akdemir A., Bakker R., Leurs R., "A G(q/11)-coupled mutant histamine H(1) receptor F435A activated solely by synthetic ligands (RASSL).", JOURNAL OF BIOLOGICAL CHEMISTRY, vol.280, pp.34741-6, 2005
HAKEMLİ KONGRE / SEMPOZYUMLARIN BİLDİRİ KİTAPLARINDA YER ALAN YAYINLAR
Şenol H., Tuncay S., Güler E.M., Seçen H., Öcal N., Akdemir A., et al.,"Bazı Uvaol Türevlerinin Sentezi ve in vitro Biyokaitivitelerinin İncelenmesi", 3rd International Convention of Pharmaceuticals and Pharmacies, İSTANBUL, TÜRKIYE, 26-29 Nisan 2017, pp.580-581
Şenol H., Tuncay S., Seçen H., Öcal N., Akdemir A., Topçu G., "Nükleer Faktör Kappa-B İnhibisyon Etkili Ursan Türevi Triterpenlerin Sentezi ", Uluslararası Katılımlı 5. İlaç Kimyası: İlaç Etkin Maddesi Tasarımı, Sentezi, Üretimi ve Standardizasyonu Kongresi, ANTALYA, TÜRKIYE, 30 Mart - 2 Nisan 2017, ss.131-131
Akdemir A., "Structurally novel isatin derivatives as putative anticancer and antifungal agents", 7th European Congress of Pharmacology (EPHAR2016), İSTANBUL, TÜRKIYE, 1-4 Temmuz 2016, pp.1-1
Ozcan Sezer S., İnci E., Öztürk Ceylan O., Akdemir A., Suzen S., Gurer Orhan H., "Design, synthesis and investigation of dual benefits of 2-methyl indole derivatives in hormone-dependent breast cancer: Aromatase inhibitory and antioxidant activity", EUROTOX 2016, Seville, ITALYA, 4-7 Eylül 2016, pp.S126-S126
Tascioglu A., Ozcan S., Akdemir A., Gurer Orhan H., "In vitro and in silico evaluation of aromatase inhibitory activity of apigenin and amentoflavone; dual benefit of St. John's Wort in postmenopausal women", EUROTOX 2016, Seville, ITALYA, 4-7 Eylül 2016, pp.S125-S125
Akdemir A., "Docking studies to investigate ligand-protein binding interactions in pharmaceutically important carbonic anhydrases", 10th international carbonic anhydrase conference, Maastricht, HOLLANDA, 12-15 Mayıs 2015, pp.1-1
Akdemir A., "Molecular modelling studies to understand the effects of bioactive compounds on DNA and gene expression", TURKHELTOX Toxicology Congress, 9th Congress of the Turkish Society of Toxicology with participation of the Hellenic Society of Toxicology, İZMİR, TÜRKIYE, 21-24 Kasım 2015, pp.1-1
Topçu G., Akdemir A., Ozturk M., Boga M., Kola U., "Abietane diterpenoids as butyrylcholinesterase inhibitors from Salvia species", 8th Joint Meeting of AFERP, ASP, GA, PSE and SIF, New York, A.B.D., 28 Temmuz - 1 Ağustos 2012, pp.1229-1229
Akdemir A., Güzel Ö., Supuran C.T., "Potent inhibitors of mitochondrial carbonic anhydrase isozymes CA-VA and CA-VB and brain-associated isozyme CA-VII", 9th international conference on Carbonic Anhydrase (CA), ANTALYA, TÜRKIYE, 11-15 Nisan 2012, pp.1-1
Akdemir A., Güzel Ö., Supuran C., "Potent inhibitors of mitochondrial carbonic anhydrase isozymes CA-VA and CA-VB and brain-associated CA-VII", 9th International conference on Carbonic Anhydrases (CA), İSTANBUL, TÜRKIYE, 11-15 Nisan 2012, pp.1-1
Akdemir A., Ulens C., Jongejan A., Smit A., Sixma T., Bertrand D., "The use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis", 18th Neuropharmacology Conference, Washington, A.B.D., 12-14 Ekim 2008, pp.25-25
Akdemir A., Jongejan A., Smit A., Smit T., Leurs R., De Esch I., "The quest for nicotinic receptor ligands by using AChBP as a template", XIXst International Symposium on Medicinal Chemistry, İSTANBUL, TÜRKIYE, 29 Ağustos - 2 Eylül 2006, pp.25-25
KİTAP ve KİTAP BÖLÜMLERİ
Akdemir A., Güzel-Akdemir Ö., "Chapter 7. The structure, physiological role and potential medicinal applications of Carbonic Anhydrase V", in: Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications, G. De Simone & C.T. Supuran, Eds., Elsevier Science, Oxford/Amsterdam , Waltham, pp.125-138, 2015
Akdemir A., Leurs R., De Esch I.J., "Chapter 3. The acetylcholine binding protein as a template for the ligand binding domains of the homologous nicotinic receptors", in: Pharmacology of nicotinic acetylcholine receptors from the basic and therapeutic perspectives, Hugo R. Arias, Eds., Research Signpost, Kerala, pp.45-70, 2011
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