The Synthesis, Anticancer Activity, Structure-Activity Relationships and Molecular Modelling Studies of Novel Isoindole-1,3(2H)-dione Compounds Containing Different Functional Groups.

Tan A., Kizilkaya S., Kelestemur U., Akdemir A., Kara Y.

Anti-cancer agents in medicinal chemistry, cilt.20, ss.1368-1378, 2020 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2174/1871520620666200410080648
  • Dergi Adı: Anti-cancer agents in medicinal chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1368-1378
  • Anahtar Kelimeler: Isoindole-1,3(2H)-dione, trimethylsilyl ether, tert-butyldiphenylsilyl ether, tert-butyldiphenylsilyl ether, MCF-7, Caco-2, molecular modeling, NORCANTHARIDIN, ANALOGS, DERIVATIVES, THALIDOMIDE, APOPTOSIS, CELLS, INHIBITION, PROPERTY
  • Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

Background: Isoindole-1,3(2H)-dione derivatives are known to have cytotoxic effects on many cancer cells. The anticancer activity of these compounds varies depending on the substituents attached to them. Therefore, the effect of substituents is very important when determining the anticancer activities of molecules. We have recently reported an example of the substituent effect.