The Synthesis, Anticancer Activity, Structure-Activity Relationships and Molecular Modelling Studies of Novel Isoindole-1,3(2H)-dione Compounds Containing Different Functional Groups.

Tan A., Kizilkaya S., Kelestemur U., Akdemir A. , Kara Y.

Anti-cancer agents in medicinal chemistry, vol.20, pp.1368-1378, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20
  • Publication Date: 2020
  • Doi Number: 10.2174/1871520620666200410080648
  • Title of Journal : Anti-cancer agents in medicinal chemistry
  • Page Numbers: pp.1368-1378
  • Keywords: Isoindole-1,3(2H)-dione, trimethylsilyl ether, tert-butyldiphenylsilyl ether, tert-butyldiphenylsilyl ether, MCF-7, Caco-2, molecular modeling, NORCANTHARIDIN, ANALOGS, DERIVATIVES, THALIDOMIDE, APOPTOSIS, CELLS, INHIBITION, PROPERTY


Background: Isoindole-1,3(2H)-dione derivatives are known to have cytotoxic effects on many cancer cells. The anticancer activity of these compounds varies depending on the substituents attached to them. Therefore, the effect of substituents is very important when determining the anticancer activities of molecules. We have recently reported an example of the substituent effect.