The Synthesis, Anticancer Activity, Structure-Activity Relationships and Molecular Modelling Studies of Novel Isoindole-1,3(2H)-dione Compounds Containing Different Functional Groups.
Anti-cancer agents in medicinal chemistry, vol.20, pp.1368-1378, 2020 (Journal Indexed in SCI)
Article / Article
Title of Journal :
Anti-cancer agents in medicinal chemistry
Isoindole-1,3(2H)-dione, trimethylsilyl ether, tert-butyldiphenylsilyl ether, tert-butyldiphenylsilyl ether, MCF-7, Caco-2, molecular modeling, NORCANTHARIDIN, ANALOGS, DERIVATIVES, THALIDOMIDE, APOPTOSIS, CELLS, INHIBITION, PROPERTY
Background: Isoindole-1,3(2H)-dione derivatives are known to have cytotoxic effects on many cancer cells. The anticancer activity of these compounds varies depending on the substituents attached to them. Therefore, the effect of substituents is very important when determining the anticancer activities of molecules. We have recently reported an example of the substituent effect.