Anticholinesterase and Antioxidant Activities of Natural Abietane Diterpenoids with Molecular Docking Studies

TOPÇU G., AKDEMİR A., Kolak U., Ozturk M., Boga M., BAHADORİ F., ...More

CURRENT ALZHEIMER RESEARCH, vol.17, no.3, pp.269-284, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.2174/1567205017666200424133534
  • Journal Name: CURRENT ALZHEIMER RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Abstracts in Social Gerontology, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE, Psycinfo
  • Page Numbers: pp.269-284
  • Keywords: Alzheimer's Disease, cholinesterase inhibition, acetylcholinesterase, butyrylcholinesterase, antioxidant, docking studies, abietane diterpenoids, Salvia, ALZHEIMERS-DISEASE, ANTIBACTERIAL DITERPENES, BIOACTIVE CONSTITUENTS, CYTOTOXIC ACTIVITY, SALVIA EXTRACTS, ROOTS, TERPENOIDS, BUTYRYLCHOLINESTERASE, INHIBITORS, THERAPY
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Background: Alzheimer's Disease (AD) is one of the most prevalent causes of dementia in the world, and no drugs available that can provide a complete cure. Cholinergic neurons of the cerebral cortex of AD patients are lost due to increased activity of cholinesterase enzymes.