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Turkiye Klinikleri Jinekoloji Obstetrik, vol.23, no.1, pp.49-52, 2013 (Scopus)
Nonimmun hydrops secondary to parvovirus B19 (PVB19 V) infection can manifest as severely as fetal death to as mild as spontaneous resolution. A positive metarnal PB19V-IgM titer has a high sensitivy for recent PB19 V infection, but its levels can decrease rapidly after the onset of disease. We presented here, a rare case of transient hydrops fetalis secondary to PVB19 Infection with negative maternal PB19 V-IgM anti bodies. A 25-years-old primigravida was referred to our institute at 23 weeks gestation with nonimmun hydrops fetalis. The fetus was noted to be hydropic with middle ascites, bilateral pleural effusion and pericardial effusion. Serological evaluation for PVB19 V indicated positive of specific IgG and negatif of IgM anti body, but the mother had symptomps such as erythema infectiosum, mild fever, arthralgia and headache two weeks ago. Maternal blood examined PVB19 V-DNA detection by PCR and PVB19 V DNA was positive. Ultrasonography revealed spontaneous resolution within 21 days. In conclusion, fetal PVB19 V in fection should be confirmed to PVB19-DNA detection by PCR in cases of doubtful serological results. Copyright © 2013 by Türkiye Klinikleri.