Serum gamma-glutamyl transferase (GGT) levels and inflammatory activity in patients with non-dipper hypertension.


ERMİŞ N., Yagmur J., Acikgoz N. , CANSEL M., Cuglan B., PEKDEMİR H., ...More

Clinical and experimental hypertension (New York, N.Y. : 1993), vol.34, no.5, pp.311-5, 2012 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 5
  • Publication Date: 2012
  • Doi Number: 10.3109/10641963.2011.577485
  • Title of Journal : Clinical and experimental hypertension (New York, N.Y. : 1993)
  • Page Numbers: pp.311-5

Abstract

Non-dipper hypertension is associated with increased cardiovascular morbidity and mortality. We aimed to evaluate serum gamma-glutamyl transferase (GGT) level, which is accepted as a marker for oxidative stress and its relationship with inflammatory activity in patients with non-dipper hypertension. Age and sex matched 43 dipper hypertensive patients, 40 non-dipper patients, and 46 healthy subjects were included into the study. Serum GGT and C-reactive protein (CRP) levels were measured and compared between each of the groups. Serum GGT activity was higher in the non-dipper and the dipper hypertensive groups than in the control group (33.5 +/- 11.8 and 28.1 +/- 10.1 U/l, respectively, vs. 21.2 +/- 6.5U/l; p < 0.001). There was a statistically significant difference in serum GGT activity between the non-dippers and the dippers (p = 0.021). When compared with the control group, serum CRP levels were significantly increased in both the non-dipper and the dipper hypertensive groups (6.1 +/- 2.6 and 5.4 +/- 2.1 mg/l, respectively, vs. 2.8 +/- 1.7mg/L; p < 0.001). Increased CRP levels were higher in non-dippers than dippers (p = 0.046). A significant correlation was found between GGT and CRP measurements (r = 0.37, p = 0.002). Serum GGT levels, which are markers of the oxidative stress and CRP levels, are both increased in non-dipper hypertension. Increased GGT activity, found to be correlated with CRP levels, may be one of the reasons behind the non-dipper hypertension related cardiovascular complications.