Histomorphometric evaluation of the effect of doxycycline on the healing of bone defects in experimental diabetes mellitus: A pilot study


ALKAN A. , Erdem E., Gunhan O., Karasu C.

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, vol.60, no.8, pp.898-904, 2002 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 8
  • Publication Date: 2002
  • Doi Number: 10.1053/joms.2002.33859
  • Title of Journal : JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
  • Page Numbers: pp.898-904

Abstract

Purpose: Bone healing is impaired in diabetes mellitus, particularly due to increased collagen breakdown. Recently, tetracyclines have been used to treat experimental bone defects because they have anticollagenolytic properties, and positive effects on the healing process have been obtained. The objective of this study was to develop a computer-assisted histomorphometric technique to quantitatively determine the amount of regenerating bone within experimental bone defects in a diabetic rodent model.