Histomorphometric evaluation of the effect of doxycycline on the healing of bone defects in experimental diabetes mellitus: A pilot study

ALKAN A., Erdem E., Gunhan O., Karasu C.

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, vol.60, no.8, pp.898-904, 2002 (SCI-Expanded) identifier identifier identifier


Purpose: Bone healing is impaired in diabetes mellitus, particularly due to increased collagen breakdown. Recently, tetracyclines have been used to treat experimental bone defects because they have anticollagenolytic properties, and positive effects on the healing process have been obtained. The objective of this study was to develop a computer-assisted histomorphometric technique to quantitatively determine the amount of regenerating bone within experimental bone defects in a diabetic rodent model.