Oxidative status and serum PON1 activity in beta-thalassemia minor


Selek S. , ASLAN M., HOROZ M., GUR M., EREL O.

CLINICAL BIOCHEMISTRY, vol.40, pp.287-291, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40
  • Publication Date: 2007
  • Doi Number: 10.1016/j.clinbiochem.2006.10.028
  • Title of Journal : CLINICAL BIOCHEMISTRY
  • Page Numbers: pp.287-291
  • Keywords: beta-thalassemia minor, PON1, oxidative stress, total antioxidant capacity, LOW-DENSITY-LIPOPROTEIN, RED-BLOOD-CELLS, ANTIOXIDANT STATUS, XYLENOL ORANGE, PARAOXONASE, INHIBITION, SURVIVAL, CHILDREN, OXIDANT, LDL

Abstract

Objectives: Paraoxonase-1 (PON1) deficiency is related to increased susceptibility to low density lipoprotein oxidation and development of atherosclerosis. The aim of this study was to investigate paraoxonase and arylesterase activities along with oxidative status parameters, and to find out if there is any increased susceptibility to atherogenesis, which might be reflected with increased oxidative stress and decreased serum PON1 activity in beta-thalassemia minor (BTM) subjects.