Oxidative status and serum PON1 activity in beta-thalassemia minor

Selek S., ASLAN M., HOROZ M., GUR M., EREL O.

CLINICAL BIOCHEMISTRY, vol.40, pp.287-291, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40
  • Publication Date: 2007
  • Doi Number: 10.1016/j.clinbiochem.2006.10.028
  • Journal Name: CLINICAL BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.287-291
  • Keywords: beta-thalassemia minor, PON1, oxidative stress, total antioxidant capacity, LOW-DENSITY-LIPOPROTEIN, RED-BLOOD-CELLS, ANTIOXIDANT STATUS, XYLENOL ORANGE, PARAOXONASE, INHIBITION, SURVIVAL, CHILDREN, OXIDANT, LDL
  • Bezmialem Vakıf University Affiliated: No

Abstract

Objectives: Paraoxonase-1 (PON1) deficiency is related to increased susceptibility to low density lipoprotein oxidation and development of atherosclerosis. The aim of this study was to investigate paraoxonase and arylesterase activities along with oxidative status parameters, and to find out if there is any increased susceptibility to atherogenesis, which might be reflected with increased oxidative stress and decreased serum PON1 activity in beta-thalassemia minor (BTM) subjects.