The effects of aqueous extract of Lavandula angustifolia flowers in glutamate-induced neurotoxicity of cerebellar granular cell culture of rat pups


BUYUKOKUROGLU M., Gepdiremen A. A. , HACIMUFTUOGLU A., OKTAY M.

JOURNAL OF ETHNOPHARMACOLOGY, cilt.84, ss.91-94, 2003 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 84 Konu: 1
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/s0378-8741(02)00286-6
  • Dergi Adı: JOURNAL OF ETHNOPHARMACOLOGY
  • Sayfa Sayısı: ss.91-94

Özet

In the present study, neuroprotective effect of Lavandula angustifolia flower aqueous extract in glutamate-induced neurotoxicity in rat pups cerebellar granular cell culture was investigated. The extract at doses of 10 mug ml(-1), 100 mug ml(-1), 1 mg ml(-1) and 10 mg ml(-1) was applied to culture flasks. The extract at doses of 100 mug ml(-1) and 1 mg ml(-1) significantly blocked glutamate-induced neurotoxicity, with the most effective dose being 1 mg ml(-1). On the other hand, 10 mg ml(-1) dose of extract increased the dead cell with respect to glutamate group, despite being found insignificant statistically. As a result, L. angustifolia protected the neurons against glutamate toxicity. (C) 2002 Published by Elsevier Science Ireland Ltd.