Targeting breast cancer using pirarubicin-loaded vasoactive intestinal peptide grafted sterically stabilized micelles


Eskandari Z., Bahadori F., Yapaoz M. A. , Yenigun V. B. , Celikten M., Kocyigit A. , ...More

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol.162, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 162
  • Publication Date: 2021
  • Doi Number: 10.1016/j.ejps.2021.105830
  • Title of Journal : EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
  • Keywords: Nanomedicine, Sterically stabilized micelle, Pirarubicin, VIP, Targeted cancer therapy, IN-VITRO, PHOSPHOLIPID MICELLES, DRUG-DELIVERY, VIP, NANOMEDICINE, VIVO, INTERNALIZATION, DERIVATIVES, FORMULATION, RECEPTORS

Abstract

In this study the chemotherapeutic agent Pirarubicin (PRB) which is known for its serious side effects was actively targeted to the breast cancer cells by uploading it to the biocompatible and biodegradable Sterically Stabilized Micelles (SSMs) made of 1,2-Distearoyl-sn-glycero-3 phosphoethanolamine-N-methoxy-polyethylene glycol 2000 (DSPE-PEG(2000)) to enhance efficacy and reduce toxicity. Vasoactive intestinal peptide (VIP), the receptors of which are overexpressed on the breast cancer cells, was grafted on the surface of the micelles. To the best of our knowledge this is the first report on active targeting of PRB to tumor site.