Elongation factor-2 kinase (eEF-2K) expression is associated with poor patient survival and promotes proliferation, invasion and tumor growth of lung cancer

Bircan H. A., Gurbuz N., Pataer A., CANER A., Kahraman N., Bayraktar E., ...More

LUNG CANCER, vol.124, pp.31-39, 2018 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 124
  • Publication Date: 2018
  • Doi Number: 10.1016/j.lungcan.2018.07.027
  • Journal Name: LUNG CANCER
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.31-39
  • Keywords: Eukaryotic elongation factor-2, eEF-2 kinase, Lung cancer, Liposomes, Rottlerin, siRNA, Signaling, Survival, Tumorigenesis, OPEN-LABEL, 1ST-LINE TREATMENT, PROTEIN-SYNTHESIS, SRC INHIBITORS, CHEMOTHERAPY, CRIZOTINIB, AUTOPHAGY, PHASE-3, TARGET, EEF2K
  • Bezmialem Vakıf University Affiliated: No

Abstract

Objectives: Lung cancer is the leading cause of cancer related deaths in worldwide. Despite recent advances in treatment options, patient survival has not improved substantially due to lack of commonly expressed molecular targets and effective targeted therapeutics. Thus, better understanding of the biology of lung cancer and identification of novel therapeutic targets are urgently needed for development of highly effective molecularly targeted therapies.