Risk and protective factors for mental disorders with onset in childhood/adolescence: An umbrella review of published meta-analyses of observational longitudinal studies

Solmi M., Dragioti E., Arango C., Radua J., Ostinelli E., KILIÇ Ö., ...More

Neuroscience and Biobehavioral Reviews, vol.120, pp.565-573, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 120
  • Publication Date: 2021
  • Doi Number: 10.1016/j.neubiorev.2020.09.002
  • Journal Name: Neuroscience and Biobehavioral Reviews
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Animal Behavior Abstracts, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, EMBASE, MEDLINE, Psycinfo, Veterinary Science Database
  • Page Numbers: pp.565-573
  • Keywords: umbrella review, Neurodevelopmental, Risk factor, Prevention, Systematic review, Meta-analysis, Childhood, Adolescence, Mental health, SYSTEMATIC REVIEWS, OBESITY, PREGNANCY, OUTCOMES, CHILDREN, EXCESS
  • Bezmialem Vakıf University Affiliated: Yes


© 2020 Elsevier LtdThe patho-etiology of mental disorders with onset in childhood or adolescence remains largely unknown. We conducted an umbrella review of meta-analyses (MAs) on environmental factors associated with mental disorders with onset in childhood/adolescence. We searched Pubmed-MEDLINE/EMBASE/PsycInfo databases, last search April 29th, 2020. Quality of MAs was measured with AMSTAR-2. Out of 6851 initial references, ten articles met inclusion criteria, providing 23 associations between 12 potential environmental factors and nine disorders (cases: 8884; N = 3,660,670). While almost half of the associations were nominally significant, none of them met criteria from either convincing or highly suggestive evidence. A single association was supported by suggestive evidence (maternal exposure to lithium or antipsychotics with neuromotor deficits), but it was affected by confounding by indication. Ten more associations had weak evidence, and 12 associations were not statistically significant. Quality of meta-analyses was rated as high in two, moderate in one, low in four, critically low in two, and not pertinent in one (individual participant data). Methodologically-sound research is needed in this field.