Antioxidant and Anticholinesterase Activities of Some Dialkylamino Substituted 3-Hydroxyflavone Derivatives

Culhaoglu B., Capan A., Boga M., Ozturk M., Öztürk T., Topcu G.

MEDICINAL CHEMISTRY, vol.13, pp.254-259, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13
  • Publication Date: 2017
  • Doi Number: 10.2174/1573406412666161104121642
  • Journal Name: MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.254-259
  • Keywords: Alzheimer's disease, anticholinesterase, antioxidant, flavonoid, flavonol, 3-hydroxyflavone, IN-VIVO, FLAVONOIDS, CONSTITUENTS, ANALOGS, MODEL, RATS
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Background: Flavones, are a class of naturally occuring polyphenolic compounds which have 2-phenylchromen-4-one structure. Various studies showed that flavones have several pharmacological activities such as antioxidant, anti-inflammatory, antimicrobial, cytotoxic, antitumour and antiallergic. In the present study, 3-hydroxyflavones also called flavonols, posessing 4'-dialkylamino moiety were synthesized, and their antioxidant and anticholinesterase activities were investigated by comparison with unmodified 3-hydroxflavone.