Gamma Glutamyl Transferase Activity is Associated With Both Paraoxonase Activity and Aortic Stiffness in Hypertensive Patients

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GOZUKARA M. Y., Borekci A., Gur M., Aksoy N., SEKER T., KAYPAKLI O., ...More

JOURNAL OF CLINICAL LABORATORY ANALYSIS, vol.29, no.5, pp.390-396, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 5
  • Publication Date: 2015
  • Doi Number: 10.1002/jcla.21785
  • Journal Name: JOURNAL OF CLINICAL LABORATORY ANALYSIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.390-396
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Background: We aimed to investigate relationship between gamma glutamyl transferase (GGT) activity with paraoxonase 1 (PON1) activity and aortic stiffness (AS) parameters such as pulse wave velocity (PWV) and augmentation index (AIx). Methods: Measurements were obtained from 324 patients with newly diagnosed essential hypertension (mean age: 55.0 +/- 8.2 years). The patients were divided into two groups according to their median GGT values. PWV and AIx were calculated using the single-point method via the Mobil-O-Graph (R) ARC-solver algorithm. Results: PWV, Aix, and high-sensitive C-reactive protein (hs-CRP) values were higher and PON1 activity values were lower in GGT(high) group compared with GGT(low) group (P < 0.05, for all). Multiple linear regression analysis showed that GGT activity was independently associated with PWV (beta = 0.496, P < 0.001) and PON1 activity (beta = -0.343, P < 0.001) as well as hs-CRP (beta = 0.334, P < 0.001). Conclusion: These results may support that increased GGT activity would be associated with both impaired antioxidant system and increased AS in hypertensive patients. (C) 2014 Wiley Periodicals, Inc.