Effects of Recombinant Activated Protein C Derived From Drotrecogin-Alpha on Bleomycin-Induced Pulmonary Fibrosis in Rats Compared with Methyl-Prednisolone

Yildiz K., Iraz M., ŞAMDANCI E., ÖZEROL E., KUKU İ., AYTEMUR Z. A., ...More

TURKISH THORACIC JOURNAL, vol.14, no.2, pp.48-52, 2013 (ESCI, Scopus, TRDizin) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 2
  • Publication Date: 2013
  • Doi Number: 10.5152/ttd.2013.10
  • Journal Name: TURKISH THORACIC JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.48-52
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

OBJECTIVE: In this study, we aimed to test the preventive effects of intraperitoneally administered drotrecogin alpha which is derived from activated protein C (APC), on bleomycin-induced pulmonary fibrosis in rats, and to compare the effects of APC with the effects of methyl-prednisolone, a traditional therapy.