Miltefosine and polyhexamethylene biguanide: a new drug combination for the treatment of Acanthamoeba keratitis

POLAT Z., WALOCHNIK J., OBWALLER A., Vural A., DURSUN A., ARICI M. K.

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, vol.42, no.2, pp.151-158, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.1111/ceo.12120
  • Title of Journal : CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • Page Numbers: pp.151-158

Abstract

BackgroundIn this study, a series of compounds - miltefosine, polyhexamethylene biguanide, chlorhexidine and propamidine isethionate - and combinations of the latter three agents with miltefosine were prepared and used in a rat model for the topical treatment of Acanthamoeba keratitis.