Miltefosine and polyhexamethylene biguanide: a new drug combination for the treatment of Acanthamoeba keratitis

POLAT Z., WALOCHNIK J., OBWALLER A., Vural A., DURSUN A., ARICI M. K.

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, cilt.42, ss.151-158, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 42 Konu: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1111/ceo.12120
  • Dergi Adı: CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • Sayfa Sayısı: ss.151-158

Özet

BackgroundIn this study, a series of compounds - miltefosine, polyhexamethylene biguanide, chlorhexidine and propamidine isethionate - and combinations of the latter three agents with miltefosine were prepared and used in a rat model for the topical treatment of Acanthamoeba keratitis.