Miltefosine and polyhexamethylene biguanide: a new drug combination for the treatment of Acanthamoeba keratitis

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POLAT Z., WALOCHNIK J., OBWALLER A., Vural A., DURSUN A., ARICI M. K.

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, vol.42, no.2, pp.151-158, 2014 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 42 Issue: 2
• Publication Date: 2014
• Doi Number: 10.1111/ceo.12120
• Journal Name: CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.151-158
• Bezmialem Vakıf University Affiliated: No

Abstract

BackgroundIn this study, a series of compounds - miltefosine, polyhexamethylene biguanide, chlorhexidine and propamidine isethionate - and combinations of the latter three agents with miltefosine were prepared and used in a rat model for the topical treatment of Acanthamoeba keratitis.