Impact of a 12-week structured exercise program on motor function and exosomal alpha-synuclein levels in Parkinson's disease: A prospective analysis

Mustafayev N., Tunç A., Elibol B., Eren K. U., Terzioglu-Usak S.

Turk Noroloji Dergisi, cilt.30, sa.2, ss.86-92, 2024 (ESCI, Scopus, TRDizin) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 2
  • Basım Tarihi: 2024
  • Doi Numarası: 10.55697/tnd.2024.8
  • Dergi Adı: Turk Noroloji Dergisi
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.86-92
  • Anahtar Kelimeler: Alpha-synuclein, combined exercise training, exosomes, Parkinson’s disease
  • Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

Objectives: This study aimed to determine whether exercise reduced alpha-synuclein aggregation and ultimately improved symptoms of Parkinson’s disease (PD). Patients and methods: The prospective study was conducted with 26 PD patients (14 males, 12 females; mean age: 58.5±11.3 years; range, 38 to 79 years) between October 2019 and January 2020. A 12-week combined exercise program, including respiratory training, spinal stabilization, and stretching, was performed by the patients. Detailed clinical assessments were conducted, along with alpha-synuclein quantification, before and after the intervention. Results: The data revealed notable improvements in motor, cognitive, and nonmotor realms (p<0.05). However, alpha-synuclein levels remained consistent (p>0.05). Conclusion: While the exercise regimen aids symptom mitigation in PD, it does not alter alpha-synuclein concentrations, emphasizing the need to further investigate the mechanisms behind the exercise-related benefits.