Dexpanthenol and ascorbic acid ameliorate colistin-induced nephrotoxicity in rats.

Aslan T., Guler E. M., Cakir A., Dundar T. T., Gulgec A. S., Huseyinbas O., ...More

European review for medical and pharmacological sciences, vol.25, no.2, pp.1016-1023, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.26355/eurrev_202101_24671
  • Journal Name: European review for medical and pharmacological sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.1016-1023
  • Keywords: Colistin-induced nephrotoxicity, Dexpanthenol, Ascorbic acid, Oxidative stress, Inflammation, APOPTOSIS
  • Bezmialem Vakıf University Affiliated: Yes


OBJECTIVE: Colistin is a potent antibiotic which is mainly preferred in the treatment of multidrug-resistant (MDR) gram-negative bacilli. However, due to the increased risk of acute kidney injury following its use, the clinical application is limited. This nephrotoxicity is known to be induced by oxidative stress and related inflammation. In this study on rats, potent antioxidants Dexpanthenol (DEX) and Ascorbic acid (Vit C) have been administered in combination with Colistin to find out whether they would weaken Colistin's nephrotoxic effects.