Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia

TAKIR, Mumtaz; KOSTEK, Osman; OZKOK, Abdullah; Elcioglu, Ömer; BAKAN, Ali; EREK, Aybala; MUTLU, Hasan; TELCI, Ozge; SEMERCI, Aysun; ODABAS, Ali; AFSAR, Baris; SMITS, Gerard; ALANASPA, Miguel; SHARMA, Shailendra; JOHNSON, Richard; Kanbay, Mehmet

doi:10.1097/jim.0000000000000242

Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia

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TAKIR M., KOSTEK O., OZKOK A., Elcioglu O. C., BAKAN A., EREK A., ...More

JOURNAL OF INVESTIGATIVE MEDICINE, vol.63, no.8, pp.924-929, 2015 (SCI-Expanded)

Publication Type: Article / Article
Volume: 63 Issue: 8
Publication Date: 2015
Doi Number: 10.1097/jim.0000000000000242
Journal Name: JOURNAL OF INVESTIGATIVE MEDICINE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.924-929
Bezmialem Vakıf University Affiliated: No

Abstract

Background Hyperuricemia is an independent predictor of impaired fasting glucose and type 2 diabetes, but whether it has a causal role in insulin resistance remains controversial. Here we tested the hypothesis that lowering uric acid in hyperuricemic nondiabetic subjects might improve insulin resistance.