Comparison of different risk factors that result in endothelial damage leading to diabetic microangiopathy

KAYACAN S., Kazancioglu R. , OFLAZ H., TUNA S.

SOUTHERN MEDICAL JOURNAL, vol.96, no.4, pp.387-390, 2003 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 96 Issue: 4
  • Publication Date: 2003
  • Doi Number: 10.1097/01.smj.0000054908.81096.4f
  • Page Numbers: pp.387-390


In this study, the effect of different risk factors (hyperglycemia, hypertension, hyperlipidemia, hyperuricemia) on endothelial damage was evaluated in 61 (two of them were type 1; the other patients were type 2) diabetic patients. von Willebrand factor antigen was used as the marker of the endothelial damage. Although there was no significant decrease (P > 0.05) in von Willebrand factor level after regulation of nonregulated diabetes, a significant decrease was determined in nonregulated and hypertensive diabetic patients after improvement of risk factors (P < 0.05). As a result, nonregulated diabetes alone has less effect than nonregulated diabetes plus other risk factors (particularly hypertension) on diabetic angiopathy.