The effect of topical ethanol extract of Cotinus coggygria Scop. on cutaneous wound healing in rats

AKSOY H., SANCAR M., ŞEN A., OKUYAN B., BİTİŞ L., Uras F., ...More

NATURAL PRODUCT RESEARCH, vol.30, no.4, pp.452-455, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1080/14786419.2015.1019349
  • Journal Name: NATURAL PRODUCT RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.452-455
  • Keywords: wound healing, hydroxyproline, Cotinus coggygria Scop, CONSTITUENTS, CHELATION, COLLAGEN
  • Bezmialem Vakıf University Affiliated: No

Abstract

The aim of this study is to determine the cutaneous wound healing effects of the ethanol extract of Cotinus coggygria leaves in rats by excision wound model to provide scientific evidence for the traditional use of C. coggygria Scop. The levels of malondialdehyde, catalase, superoxide dismutase, glutathione and hydroxyproline were investigated in wound tissues. Histopathological examination was also performed. The hydroxyproline content of the granulation tissue and the glutathione levels were both significantly higher in the treatment group than in the control group (p < 0.05 for both); while the malondialdehyde levels were significantly lower in the treatment group (p < 0.05). These results were supported with histological results. The ethanol extract of C. coggygria Scop could be considered as an effective agent in wound healing in accordance with its traditional use.