Effects of sitagliptin on ß-adrenoceptor mediated relaxation in streptozotocin-diabetic rat aorta.


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MÜderrİsoĞlu A. E. , ErdoĞan B. R. , YeŞİlyurt Z. E. , Uyar BoztaŞ C., KaraÖmerlİoĞlu İ., Altan V. M. , ...More

Turkish journal of medical sciences, vol.51, pp.864-872, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51
  • Publication Date: 2021
  • Doi Number: 10.3906/sag-2007-234
  • Title of Journal : Turkish journal of medical sciences
  • Page Numbers: pp.864-872
  • Keywords: beta-adrenoceptors, aorta, streptozotocin induced diabetes, sitagliptin, endothelial nitric oxide synthase, NITRIC-OXIDE SYNTHASE, ENDOTHELIAL DYSFUNCTION, EXPRESSION, INHIBITOR

Abstract

Background/aim: Dipeptidyl peptidase-4 (DPP4) inhibitors, a class of oral antidiabetic drugs, have been shown to be protective on the vascular system because of their antiinflammatory, antiatherosclerotic, and vasodilatory effects. beta(2)-adrenoceptors (beta(2)-ARs) mediate the vasorelaxation in the aorta. However, beta(3)-adrenoceptor-mediated relaxation has not been studied in diabetic aorta yet. Thus, we aimed to study the effect of sitagliptin treatment on beta(2)- and beta(3)-adrenoceptor-mediated relaxations in the diabetic rat aorta.