Growth Arrest-Specific 6 and Cardiometabolic Risk Factors in Patients with Psoriasis

SÜNBÜL M., Cagman Z., Gerin F., ÖZGEN Z., Durmus E., Seckin D., ...More

CARDIOVASCULAR THERAPEUTICS, vol.33, no.2, pp.56-61, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.1111/1755-5922.12112
  • Journal Name: CARDIOVASCULAR THERAPEUTICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.56-61
  • Keywords: Atherosclerosis, Growth Arrest-Specific 6, Psoriasis, Risk Factors, SYSTEMIC-LUPUS-ERYTHEMATOSUS, K-DEPENDENT PROTEINS, SMOOTH-MUSCLE-CELLS, TAM RECEPTORS, CARDIOVASCULAR RISK, DISEASE-ACTIVITY, VASCULAR CALCIFICATION, PLASMA-CONCENTRATIONS, ARTERIAL STIFFNESS, ENDOTHELIAL-CELLS
  • Bezmialem Vakıf University Affiliated: No

Abstract

ObjectivesAn increased risk for cardiovascular disease with psoriasis has been reported. Growth Arrest-Specific 6 (GAS6) amplifies pro-inflammatory endothelial cell activation via TAM receptors. However, it also inhibits inflammation by multiple mechanisms including phagocytosis. The objective of this study was to investigate whether plasma GAS6 levels are associated with conventional cardiometabolic (CM) risk factors in patients with psoriasis.