Sunar İ., Kahveci A., Ataman Ş., Bodur H., Ecesoy H., Albayrak Gezer I., ...Daha Fazla
ANNALS OF THE RHEUMATIC DISEASES, cilt.84, ss.1871-1872, 2025 (SCI-Expanded, Scopus)
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Yayın Türü:
Makale / Özet
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Cilt numarası:
84
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Basım Tarihi:
2025
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Doi Numarası:
10.1016/j.ard.2025.06.1391
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Dergi Adı:
ANNALS OF THE RHEUMATIC DISEASES
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database, Nature Index
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Sayfa Sayıları:
ss.1871-1872
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Bezmiâlem Vakıf Üniversitesi Adresli:
Evet
Özet
Background:
Psoriatic
arthritis (PsA) is an inflammatory disease with skin and
musculoskeletal manifestations as well as systemic consequences. While
patients with skin or nail lesions antedating or evolving simultaneously
as rheumatologic involvement constitute the majority of cases, others
are called PsA sine psoriasis.
Objectives:
Our
objective is to evaluate the frequency of PsA sine psoriasis patients
and compare them with classical PsA in terms of clinicodemographic
variables, disease activity, and quality of life using data from a
multicenter registry.
Methods:
PsA
patients meeting the Classification criteria for Psoriatic Arthritis
(CASPAR) registered in a multi-centre Turkish League Against Rheumatism
(TLAR) Network Project were screened. Demographic and clinical data
including detailed history, radiographic data, tender and swollen joint
counts, body mass index (BMI), the Disease Activity Index for Psoriatic
Arthritis (DAPSA), Bath Ankylosing Spondylitis Disease Activity Index
(BASDAI); Maastricht Ankylosing Spondylitis Enthesitis Score (MASES),
Health Assessment Questionnaire (HAQ); Bath Ankylosing Spondylitis
Functional Index (BASFI); Psoriatic arthritis quality of Life scale
(PsAQoL), Short Form 36 (SF-36); Functional Assessment of Chronic
Illness Therapy-Fatigue (FACIT-F), and Fibromyalgia Rapid
Screening Tool (FiRST) were retrieved from electronical records. The
patients were divided into two main groups according to the onset of
skin lesions and arthritis. The patients with presentation of arthritis
were labeled as ‘Total PsA sine psoriasis' and the remainder were
classical PsA patients. Patients who did not ever have skin involvement
were accepted as ‘current PsA sine psoriasis'. Comparisons were
performed between three groups.
Results:
This
study included 1346 PsA patients with a mean age of 47.10 (±12.32)
years. Of the patients, 64.8% were women. Three groups were similar in
terms of age, BMI, and gender (p>0.05). A total of 216 (16.05%)
patients had presented with articular complaints prior to skin
involvement and labeled as ‘PsA sine psoriasis'. Forty one (3.05%)
patients still lacked psoriatic skin disease and called as ‘current sine
psoriasis' and the remainder were ‘classical PsA'. Compared to
classical PsA, sine psoriasis patients tended to have significantly
longer diagnostic delay, higher rate of family history of psoriatic
disease and IBD, and spondylitis (p<0.001, p=0.030, p=0.005,
p=0.007). They also had higher MASES, BASFI, PsAQoL, FACIT, and HAQ
scores (p=0.009, p=0.027, p=0.003, p=0.003, p=0.015 respectively). The
groups were similar in terms of DAPSA and BASDAI scores (p=0.108,
p=0.135) (Table 1).
Conclusion:
The
frequency of PsA sine psoriasis was 16.05% in this multi-center
national study. PsA sine psoriasis patients had significantly longer
diagnostic delay, higher rate of IBD, and spondylitis. These patients
had similar disease activity scores depicted by DAPSA and BASDAI but
lower quality of life and impaired functionality shown by PsAQoL, BASFI,
SF-36, FACIT, and HAQ scores.