Ivabradine treatment prevents dobutamine-induced increase in heart rate in patients with acute decompensated heart failure


ÇAVUŞOĞLU Y., MERT K. U. , Nadir A. , MUTLU F., Morrad B., ULUS T.

JOURNAL OF CARDIOVASCULAR MEDICINE, vol.16, no.9, pp.603-609, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 9
  • Publication Date: 2015
  • Doi Number: 10.2459/jcm.0000000000000033
  • Title of Journal : JOURNAL OF CARDIOVASCULAR MEDICINE
  • Page Numbers: pp.603-609
  • Keywords: acute heart failure, dobutamine, ivabradine, CORONARY-ARTERY-DISEASE, RATE REDUCTION, CONTROLLED-TRIAL, BETA-BLOCKERS, FUNNY CURRENT, RISK-FACTOR, OUTCOMES, MORTALITY, DEATH

Abstract

Background Ivabradine is a heart rate (HR)-lowering agent acting by inhibiting the I-f-channel. Dobutamine does increase the HR and has some deleterious effects on myocardium. So, we aimed to evaluate whether ivabradine treatment blunts a dobutamine-induced increase in HR.