Thymoquinone ameliorates delayed cerebral injury and cerebral vasospasm secondary to experimental subarachnoid haemorrhage.

Creative Commons License

Akkaya E., Evran Ş., Çalış F., Çevik S., Katar S., Karataş E., ...More

Neurologia i neurochirurgia polska, vol.54, pp.576-584, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54
  • Publication Date: 2020
  • Doi Number: 10.5603/pjnns.a2020.0090
  • Journal Name: Neurologia i neurochirurgia polska
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.576-584
  • Keywords: aneurysm, thymoquinone, oxidative stress, subarachnoid haemorrhage, cerebral vasospasm, delayed cerebral injury, ISCHEMIA-REPERFUSION INJURY, NIGELLA-SATIVA, BRAIN, MODEL, NEURODEGENERATION, PROLIFERATION, NEURONS, SEED
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Aim of the study. Among subarachnoid haemorrhage (SAH) patients, delayed cerebral injury (DCI) and infarction are the most important causes of death and major disability. Cerebral vasospasm (cVS) and DCI remain the major cause of death and disability. Thymoquinone (TQ) is the substance most responsible for the biological activity of nigella sativa (NS) and is useful in the treatment of ischaemic and neurodegenerative diseases, oxidative stress, inflammatory events, cardiovascular and neurological diseases. We conducted an experimental study aimed to investigate the preventive and corrective effects of TQ.