Thymoquinone ameliorates delayed cerebral injury and cerebral vasospasm secondary to experimental subarachnoid haemorrhage.

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Akkaya E., Evran Ş., Çalış F., Çevik S., Katar S., Karataş E., ...Daha Fazla

Neurologia i neurochirurgia polska, cilt.54, ss.576-584, 2020 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54
  • Basım Tarihi: 2020
  • Doi Numarası: 10.5603/pjnns.a2020.0090
  • Dergi Adı: Neurologia i neurochirurgia polska
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.576-584
  • Anahtar Kelimeler: aneurysm, thymoquinone, oxidative stress, subarachnoid haemorrhage, cerebral vasospasm, delayed cerebral injury, ISCHEMIA-REPERFUSION INJURY, NIGELLA-SATIVA, BRAIN, MODEL, NEURODEGENERATION, PROLIFERATION, NEURONS, SEED
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

Aim of the study. Among subarachnoid haemorrhage (SAH) patients, delayed cerebral injury (DCI) and infarction are the most important causes of death and major disability. Cerebral vasospasm (cVS) and DCI remain the major cause of death and disability. Thymoquinone (TQ) is the substance most responsible for the biological activity of nigella sativa (NS) and is useful in the treatment of ischaemic and neurodegenerative diseases, oxidative stress, inflammatory events, cardiovascular and neurological diseases. We conducted an experimental study aimed to investigate the preventive and corrective effects of TQ.