Thymoquinone ameliorates delayed cerebral injury and cerebral vasospasm secondary to experimental subarachnoid haemorrhage.


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Akkaya E., Evran Ş., Çalış F., Çevik S., Katar S., Karataş E., ...More

Neurologia i neurochirurgia polska, vol.54, pp.576-584, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54
  • Publication Date: 2020
  • Doi Number: 10.5603/pjnns.a2020.0090
  • Title of Journal : Neurologia i neurochirurgia polska
  • Page Numbers: pp.576-584
  • Keywords: aneurysm, thymoquinone, oxidative stress, subarachnoid haemorrhage, cerebral vasospasm, delayed cerebral injury, ISCHEMIA-REPERFUSION INJURY, NIGELLA-SATIVA, BRAIN, MODEL, NEURODEGENERATION, PROLIFERATION, NEURONS, SEED

Abstract

Aim of the study. Among subarachnoid haemorrhage (SAH) patients, delayed cerebral injury (DCI) and infarction are the most important causes of death and major disability. Cerebral vasospasm (cVS) and DCI remain the major cause of death and disability. Thymoquinone (TQ) is the substance most responsible for the biological activity of nigella sativa (NS) and is useful in the treatment of ischaemic and neurodegenerative diseases, oxidative stress, inflammatory events, cardiovascular and neurological diseases. We conducted an experimental study aimed to investigate the preventive and corrective effects of TQ.