Neural precursor cell-expressed developmentally down-regulated 4-like: a new biomarker in the pathophysiology of endometrial cancer

YILMAZ E., GÜL M., MELEKOĞLU R., Coskun E. I., Sahin N., GÜL S., ...More

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, vol.46, no.9, pp.3709-3716, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 9
  • Publication Date: 2018
  • Doi Number: 10.1177/0300060518777944
  • Journal Name: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3709-3716
  • Keywords: NEDD4L, endometrial cancer, ubiquitin, tumorigenesis, endometrial hyperplasia, immunohistochemistry, NEDD4L EXPRESSION, DEGRADATION, PROGNOSIS, RECEPTOR, GENE
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Objectives Endometrial cancer is the most frequent tumor of the female genital tract. Ubiquitin is a small protein (8.5 kDa) found in all eukaryotic cells, binds to substrate proteins via a three-phase enzymatic pathway referred to as ubiquitination and plays an important role in cellular stability. Neural precursor cell-expressed developmentally down-regulated 4-like (NEDD4L) functions in the last phase of this enzymatic process. In this study, we investigated NEDD4L protein expression in endometrial cancer.