JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, vol.46, no.9, pp.3709-3716, 2018 (SCI-Expanded)
Article / Article
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
Science Citation Index Expanded (SCI-EXPANDED), Scopus
NEDD4L, endometrial cancer, ubiquitin, tumorigenesis, endometrial hyperplasia, immunohistochemistry, NEDD4L EXPRESSION, DEGRADATION, PROGNOSIS, RECEPTOR, GENE
Bezmialem Vakıf University Affiliated:
Objectives Endometrial cancer is the most frequent tumor of the female genital tract. Ubiquitin is a small protein (8.5 kDa) found in all eukaryotic cells, binds to substrate proteins via a three-phase enzymatic pathway referred to as ubiquitination and plays an important role in cellular stability. Neural precursor cell-expressed developmentally down-regulated 4-like (NEDD4L) functions in the last phase of this enzymatic process. In this study, we investigated NEDD4L protein expression in endometrial cancer.