Neural precursor cell-expressed developmentally down-regulated 4-like: a new biomarker in the pathophysiology of endometrial cancer


YILMAZ E., GÜL M., MELEKOĞLU R., Coskun E. I. , Sahin N. , GÜL S., et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.46, ss.3709-3716, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 46 Konu: 9
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1177/0300060518777944
  • Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Sayfa Sayısı: ss.3709-3716

Özet

Objectives Endometrial cancer is the most frequent tumor of the female genital tract. Ubiquitin is a small protein (8.5 kDa) found in all eukaryotic cells, binds to substrate proteins via a three-phase enzymatic pathway referred to as ubiquitination and plays an important role in cellular stability. Neural precursor cell-expressed developmentally down-regulated 4-like (NEDD4L) functions in the last phase of this enzymatic process. In this study, we investigated NEDD4L protein expression in endometrial cancer.