BENEFICIAL EFFECT OF INSULIN ON THE DECREASED GASTROINTESTINAL BETA-ADRENERGIC RESPONSES IN STREPTOZOTOCIN-DIABETIC RATS - A CONTRIBUTING ROLE OF PROTEIN-BIOSYNTHESIS


OZTURK Y., ALTAN V. M. , OZCELIKAY A., YILDIZOGLUARI N.

ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE, vol.317, pp.81-92, 1992 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 317
  • Publication Date: 1992
  • Title of Journal : ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE
  • Page Numbers: pp.81-92

Abstract

The beneficial effect of insulin on the decreased gastrointestinal beta-adrenergic responses in experimentally diabetic rats has been reported. The effects of streptozotocin-induced diabetes and insulin on the isolated rat duodenum, precontracted with bethanecol, were examined in the absence and in the presence of protein synthesis inhibitors in isometric conditions. Streptozotocin-induced diabetes caused a decrease of the beta-adrenergic responses of the rat duodenum. In vitro insulin treatment corrected the decreased beta-adrenergic responses of rat duodenum due to streptozotocin-induced diabetes. In the presence of protein synthesis inhibitors, actinomycin D or cycloheximide, the beneficial effect of insulin on the decreased intestinal beta-adrenergic responses was significantly inhibited. These findings suggest that the beneficial effect of insulin in the rat duodenum might be related to a new receptor synthesis.