BENEFICIAL EFFECT OF INSULIN ON THE DECREASED GASTROINTESTINAL BETA-ADRENERGIC RESPONSES IN STREPTOZOTOCIN-DIABETIC RATS - A CONTRIBUTING ROLE OF PROTEIN-BIOSYNTHESIS


OZTURK Y., ALTAN V. M. , OZCELIKAY A., YILDIZOGLUARI N.

ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE, cilt.317, ss.81-92, 1992 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 317
  • Basım Tarihi: 1992
  • Dergi Adı: ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE
  • Sayfa Sayıları: ss.81-92

Özet

The beneficial effect of insulin on the decreased gastrointestinal beta-adrenergic responses in experimentally diabetic rats has been reported. The effects of streptozotocin-induced diabetes and insulin on the isolated rat duodenum, precontracted with bethanecol, were examined in the absence and in the presence of protein synthesis inhibitors in isometric conditions. Streptozotocin-induced diabetes caused a decrease of the beta-adrenergic responses of the rat duodenum. In vitro insulin treatment corrected the decreased beta-adrenergic responses of rat duodenum due to streptozotocin-induced diabetes. In the presence of protein synthesis inhibitors, actinomycin D or cycloheximide, the beneficial effect of insulin on the decreased intestinal beta-adrenergic responses was significantly inhibited. These findings suggest that the beneficial effect of insulin in the rat duodenum might be related to a new receptor synthesis.