Effects of intranasal estradiol treatment on serum lipoprotein(a) and lipids in hysterectomized women

Kiran H., Kiran G., Ekerbicer H. C., Kilinc M.

Gynecologic and Obstetric Investigation, vol.57, no.4, pp.191-195, 2004 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 4
  • Publication Date: 2004
  • Doi Number: 10.1159/000076627
  • Journal Name: Gynecologic and Obstetric Investigation
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.191-195
  • Keywords: Cardiovascular disease, Estrogen, Lipids, Lipoprotein(a), Menopause
  • Bezmialem Vakıf University Affiliated: No


The aim of the present study was to evaluate the effects of intranasal estradiol on lipid metabolism and lipoprotein(a) [Lp(a)] levels. A prospective comparative study was designed: 49 hysterectomized, healthy postmenopausal women received intranasal 17β-estradiol (E2; 300 Iμg/day). Blood samples were collected at baseline and at the end of the 3 and 6 months of therapy. After 6 months, the serum levels of total cholesterol, LDL-cholesterol and triglycerides did not show any significant change with intranasal 17β-E2 therapy. HDL-cholesterol levels at 3 and 6 months of treatment were significantly increased compared with baseline levels (p = 0.031, p = 0.000, respectively). There was a significant change in serum Lp(a) levels at the 6th month (p = 0.003) but not at the 3rd month (p = 0.183) compared with the baseline levels. Further studies are needed to detect whether these changes are significant and permanent or not. Copyright © 2004 S. Karger AG, Basel.