Relationship between the corpus callosum and neurocognitive disabilities in children with NF-1: diffusion tensor imaging features

Aydin S., Kurtcan S., Alkan A., GULER S., FILIZ M., YILMAZ T. F., ...Daha Fazla

CLINICAL IMAGING, cilt.40, sa.6, ss.1092-1095, 2016 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.clinimag.2016.06.013
  • Dergi Adı: CLINICAL IMAGING
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1092-1095
  • Anahtar Kelimeler: Neurofibromatosis type 1, Corpus callosum, Diffusion tensor imaging, Demyelination, WHITE-MATTER INTEGRITY, NEUROFIBROMATOSIS TYPE-1, BRAIN, EVOLUTION, MRI
  • Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

Purpose: Mild neurocognitive disabilities are commonly observed in children with neurofibromatosis type 1 (NF-1). Enlargement of the corpus callosum (CC) is one of the findings in NF-1, but the pathogenesis has not yet been clarified. In this study, we investigated whether diffusion tensor imaging (DTI) features of CC differed between children with NF-1 and healthy control subjects, and we tried to evahlate the association between the microstructural integrity of CC and neurocognitive disabilities, based on apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values.