Relationship between the corpus callosum and neurocognitive disabilities in children with NF-1: diffusion tensor imaging features

Aydin S. , Kurtcan S. , Alkan A. , GULER S., FILIZ M., YILMAZ T. F. , ...Daha Fazla

CLINICAL IMAGING, cilt.40, sa.6, ss.1092-1095, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 40 Konu: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.clinimag.2016.06.013
  • Sayfa Sayıları: ss.1092-1095


Purpose: Mild neurocognitive disabilities are commonly observed in children with neurofibromatosis type 1 (NF-1). Enlargement of the corpus callosum (CC) is one of the findings in NF-1, but the pathogenesis has not yet been clarified. In this study, we investigated whether diffusion tensor imaging (DTI) features of CC differed between children with NF-1 and healthy control subjects, and we tried to evahlate the association between the microstructural integrity of CC and neurocognitive disabilities, based on apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values.