Relationship between the corpus callosum and neurocognitive disabilities in children with NF-1: diffusion tensor imaging features

Aydin S. , Kurtcan S. , Alkan A. , GULER S., FILIZ M., YILMAZ T. F. , ...More

CLINICAL IMAGING, vol.40, no.6, pp.1092-1095, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 6
  • Publication Date: 2016
  • Doi Number: 10.1016/j.clinimag.2016.06.013
  • Title of Journal : CLINICAL IMAGING
  • Page Numbers: pp.1092-1095
  • Keywords: Neurofibromatosis type 1, Corpus callosum, Diffusion tensor imaging, Demyelination, WHITE-MATTER INTEGRITY, NEUROFIBROMATOSIS TYPE-1, BRAIN, EVOLUTION, MRI


Purpose: Mild neurocognitive disabilities are commonly observed in children with neurofibromatosis type 1 (NF-1). Enlargement of the corpus callosum (CC) is one of the findings in NF-1, but the pathogenesis has not yet been clarified. In this study, we investigated whether diffusion tensor imaging (DTI) features of CC differed between children with NF-1 and healthy control subjects, and we tried to evahlate the association between the microstructural integrity of CC and neurocognitive disabilities, based on apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values.