Akademik Veri Yönetim Sistemi
Cardiovascular and Hematological Disorders - Drug Targets, 2026 (Scopus)
Introduction High-sensitivity cardiac troponin I (hs-cTnI) is a precise biomarker of myocardial injury and a potential predictor of future cardiovascular events. However, data on its prognostic value in the general population of Central Asia, including the Kyrgyz Republic, are scarce. Therefore, this study aimed to evaluate the prognostic significance of hs-cTnI for cardiovascular events in the general population of the Chuy region, Kyrgyz Republic. Methods This study was conducted as part of the “Interepid” project on a representative sample (n = 1275; age range 20-64 years). Serum hs-cTnI concentrations were measured using a chemiluminescent immunoassay (Abbott Architect i2000SR). Participants were followed for seven years. The primary endpoint included both fatal and nonfatal cardiovascular events. Data were analyzed using Cox proportional hazards regression models adjusted for traditional cardiovascular risk factors. Results During the follow-up period, 179 cardiovascular events occurred (16.7%). Elevated hs-cTnI levels were independently associated with a higher risk of adverse outcomes (hazard ratio [HR] 1.23; 95% confidence interval [CI] 1.05-1.42). The strongest associations were observed among Kyrgyz women and Slavic men, whereas weaker associations were found in Kyrgyz men. The hs-cTnI thresholds associated with increased risk were ≥2.3 ng/L for men and ≥0.4 ng/L for women. Discussion In this first population-based study from the Kyrgyz Republic, elevated hs-cTnI concentrations were independently associated with cardiovascular morbidity and mortality across sex and ethnic subgroups. The observed association likely reflects subclinical myocardial injury influenced by multiple factors rather than a direct causal relationship. Lower hs-cTnI thresholds associated with risk compared with European cohorts may indicate ethnic differences, highlighting the importance of region-specific approaches to cardiovascular risk assessment. Conclusion High-sensitivity cardiac troponin I is an independent predictor of cardiovascular events in the general population of the Chuy region. The elevated risk observed at lower hs-cTnI levels compared with European populations should be considered in the development of national cardiovascular prevention strategies.