Effects of Intrathecal Verapamil on Cerebral Vasospasm in Experimental Rat Study.


Akkaya E., Evran S., Calis F., Cevik S., Hanimoglu H., SEYİTHANOĞLU M. H. , ...More

World neurosurgery, vol.127, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 127
  • Publication Date: 2019
  • Doi Number: 10.1016/j.wneu.2019.04.050
  • Title of Journal : World neurosurgery
  • Keywords: Aneurysm, Apoptosis, Endothelin-1, Intrathecal verapamil, Oxidative stress, Subarachnoid hemorrhage, Vasospasm, ANEURYSMAL SUBARACHNOID HEMORRHAGE, CISTERNAL IRRIGATION, MODEL, NIMODIPINE, PREVENTION, MANAGEMENT, MECHANISMS, INFUSION, RELEASE

Abstract

BACKGROUND: Verapamil a calcinarn channel blacker, has shown promising results on cerebral vasospasm. However, it has not yet been accepted for treatment or prevention purposes because of the associated side effects, Although the effective results of nimodipine and nicardipine's intrathecal administration are well known, intrathecal verapamil has not been considered earlier. We used an experimental subarachnoid hemorrhage induced vasospasm model for the evaluation of vasodilator and neuroprotective effects of intrathecal verapamil,