Effects of Intrathecal Verapamil on Cerebral Vasospasm in Experimental Rat Study.


Akkaya E., Evran S., Calis F., Cevik S., Hanimoglu H., SEYİTHANOĞLU M. H. , ...Daha Fazla

World neurosurgery, cilt.127, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

BACKGROUND: Verapamil a calcinarn channel blacker, has shown promising results on cerebral vasospasm. However, it has not yet been accepted for treatment or prevention purposes because of the associated side effects, Although the effective results of nimodipine and nicardipine's intrathecal administration are well known, intrathecal verapamil has not been considered earlier. We used an experimental subarachnoid hemorrhage induced vasospasm model for the evaluation of vasodilator and neuroprotective effects of intrathecal verapamil,