Synthesis, Characterization, Molecular Docking and in vitro Biological Studies of Thiazolidin‐4‐one Derivatives as Anti‐Breast‐Cancer Agents

Şenol H., Ağgül A. G., Atasoy S.

CHEMISTRYSELECT, vol.8, no.20, pp.1-10, 2023 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 20
  • Publication Date: 2023
  • Doi Number: 10.1002/slct.202300481
  • Journal Name: CHEMISTRYSELECT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Page Numbers: pp.1-10
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

In this study, 16 new compounds were synthesized starting from methylparaben. These new compounds consist of eight arylidenehydrazide derivatives and eight thiazolidin-4-on derivatives. All compounds were tested against MCF-7 breast cancer cells and MCF10A breast healthy tissue to determine their anti-cancer activity. Molecular docking studies were also carried out against receptor proteins related to the growth factor of cancer cells to understand inhibition mechanism. According to the results, 4-furan-2-ylmethoxy)-N-(4-oxo-2-phenylthiazolidin-3-yl)benzamide (5 a) and 4-(furan-2-ylmethoxy)-N-(2-(4-nitrophenyl)-4-oxothiazolidin-3-yl)benzamide (5 e) were found as the highest selective and most active compounds against breast cancer cells.