Synthesis, Characterization, Molecular Docking and in vitro Biological Studies of Thiazolidin‐4‐one Derivatives as Anti‐Breast‐Cancer Agents

Şenol H., Ağgül A. G., Atasoy S.

CHEMISTRYSELECT, cilt.8, sa.20, ss.1-10, 2023 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 20
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1002/slct.202300481
  • Dergi Adı: CHEMISTRYSELECT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Sayfa Sayıları: ss.1-10
  • Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

In this study, 16 new compounds were synthesized starting from methylparaben. These new compounds consist of eight arylidenehydrazide derivatives and eight thiazolidin-4-on derivatives. All compounds were tested against MCF-7 breast cancer cells and MCF10A breast healthy tissue to determine their anti-cancer activity. Molecular docking studies were also carried out against receptor proteins related to the growth factor of cancer cells to understand inhibition mechanism. According to the results, 4-furan-2-ylmethoxy)-N-(4-oxo-2-phenylthiazolidin-3-yl)benzamide (5 a) and 4-(furan-2-ylmethoxy)-N-(2-(4-nitrophenyl)-4-oxothiazolidin-3-yl)benzamide (5 e) were found as the highest selective and most active compounds against breast cancer cells.