Protective effects of erdosteine on doxorubicin-induced hepatotoxicity in rats


Yagmurca M., Bas O., Mollaoglu H., Sahin O., Nacar A., Karaman Ö. , ...More

ARCHIVES OF MEDICAL RESEARCH, vol.38, no.4, pp.380-385, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 4
  • Publication Date: 2007
  • Doi Number: 10.1016/j.arcmed.2007.01.007
  • Title of Journal : ARCHIVES OF MEDICAL RESEARCH
  • Page Numbers: pp.380-385
  • Keywords: erdosteine, doxorubicin, hepatotoxicity, antioxidant, ACID PHENETHYL ESTER, TISSUE XANTHINE-OXIDASE, NITRIC-OXIDE, HEPATIC TOXICITY, INDUCED CARDIOTOXICITY, SUPEROXIDE-DISMUTASE, LIPID-PEROXIDATION, INJURY, INHIBITION, REDUCTION

Abstract

Background. Oxidative stress has an important role in the pathogenesis of doxorubicin-induced hepatotoxicity. The aim of this study was to investigate the hepatoprotective effects of erdosteine, an antioxidant agent, on doxorubicin-induced hepatotoxicity.