Evaluation of children with steroid-sensitive nephrotic syndrome in terms of allergies

Yilmaz D., Yenigun A., Sonmez F., Omurlu I. K.

RENAL FAILURE, vol.37, no.3, pp.387-391, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.3109/0886022x.2014.996087
  • Journal Name: RENAL FAILURE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.387-391
  • Keywords: Atopy, IgE, minimal change disease, nephrotic syndrome, skin prick test, MINIMAL-CHANGE DISEASE, UP-REGULATION, SERUM IGE, CHILDHOOD, INTERLEUKIN-13, ATOPY, PATHOGENESIS, PODOCYTES, DISORDER, GAMMA
  • Bezmialem Vakıf University Affiliated: No


Background: The etiology of minimal-change disease is not fully known, it is believed to be mediated by the immune system. Minimal-change disease also reported as having association with atopy. In this study, atopy history, the levels of serum IgE, and skin prick test in children with steroid-sensitive nephrotic syndrome were investigated. Methods: A group of 30 children (mean age 7.7 +/- 2.2 years, 56.6% male) diagnosed with steroid-sensitive nephrotic syndrome were included in the study. Serum immunoglobulin E levels and eosinophil counts were evaluated in children with steroid-sensitive nephrotic syndrome both in relapse and remission. Skin prick test was performed in remission. Results: Of the 30 children investigated, 11 (36.7%) had a history of atopy. The median serum total IgE levels in nephrotic children in relapse, with (445 IU/mL) and without atopy (310 IU/mL) were significantly higher than those in remission (respectively, 200 IU/mL, p = 0.021, and 42 IU/mL, p = 0.001). The skin prick tests for all the allergens were evaluated as negative in all the patients. Conclusion: It was thought that increased IgE may reflect the activation of immune mechanism following various stimuli rather than a direct association with atopy in children with steroid-sensitive nephrotic syndrome.