Profiling Deleterious Non-synonymous SNPs of Smoker's Gene CYP1A1


Ramesh A. S. , Khan I. , Farhan M., Thiagarajan P.

CELL BIOCHEMISTRY AND BIOPHYSICS, vol.67, no.3, pp.1391-1396, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 67 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1007/s12013-013-9671-z
  • Title of Journal : CELL BIOCHEMISTRY AND BIOPHYSICS
  • Page Numbers: pp.1391-1396

Abstract

CYP1A1 gene belongs to the cytochrome P450 family and is known better as smokers' gene due to its hyperactivation as a consequence of long term smoking. The expression of CYP1A1 induces polycyclic aromatic hydrocarbon production in the lungs, which when over expressed, is known to cause smoking related diseases, such as cardiovascular pathologies, cancer, and diabetes. Single nucleotide polymorphisms (SNPs) are the simplest form of genetic variations that occur at a higher frequency, and are denoted as synonymous and non-synonymous SNPs on the basis of their effects on the amino acids. This study adopts a systematic in silico approach to predict the deleterious SNPs that are associated with disease conditions. It is inferred that four SNPs are highly deleterious, among which the SNP with rs17861094 is commonly predicted to be harmful by all tools. Hydrophobic (isoleucine) to hydrophilic (serine) amino acid variation was observed in the candidate gene. Hence, this investigation aims to characterize a candidate gene from 159 SNPs of CYP1A1.