The effect of naloxone on the blood levels of morphine and histamine in morphine dependent dogs


Akcasu A., Akkan A. G. , Yillar D., Aksoy I.

International Journal of Clinical Pharmacology Therapy and Toxicology, vol.26, no.6, pp.317-319, 1988 (Refereed Journals of Other Institutions) identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 6
  • Publication Date: 1988
  • Title of Journal : International Journal of Clinical Pharmacology Therapy and Toxicology
  • Page Numbers: pp.317-319

Abstract

Naloxone administration to morphine dependent dogs has caused an increase in the blood level of morphine, which was transient and statistically significant up to 1 min following the injection of the drug, although concomitant increase in the blood histamine level was not observed. Subsequent injection of naloxone has failed to produce an increase in the blood level of morphine. Likewise, injection of naloxone to morphine dependent dogs pretreated with compound 48/80, a potent mast cell depleter, revealed no increase in the blood level of morphine. This was attributed to the fact that, the origin of morphine, released into the blood, was the mast cells.