Possible Association of PER2/PER3 Variable Number Tandem Repeat Polymorphism Variants with Susceptibility and Clinical Characteristics in Pancreatic Cancer

Dagmura H., Yigit S., Nursal A. F., Duman E., Gumusay O.

GENETIC TESTING AND MOLECULAR BIOMARKERS, vol.25, no.2, pp.124-130, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.1089/gtmb.2020.0179
  • Journal Name: GENETIC TESTING AND MOLECULAR BIOMARKERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, EMBASE, MEDLINE
  • Page Numbers: pp.124-130
  • Keywords: pancreas, cancer, PER2, PER3, PCR, VNTR, GENE LENGTH POLYMORPHISM, PER3 VNTR POLYMORPHISM, CIRCADIAN CLOCK GENES, PROGNOSTIC RELEVANCE, COLORECTAL ADENOMA, EXPRESSION, RISK
  • Bezmialem Vakıf University Affiliated: No

Abstract

Objective: Pancreatic cancer (PC) is a serious disease with poor outcomes, and its prevalence has been increasing steadily. The circadian rhythm (CR) is involved in multiple physiological events and maintains homeostasis. Alterations in the CR elevate the risk of developing cancer. The present case-control research was carried out to estimate the possible association between PERIOD2/PERIOD3 (PER2/PER3) gene variable number tandem repeat polymorphism (VNTR) variants and PC in the Turkish population.