Akademik Veri Yönetim Sistemi
Duzce Medical Journal, cilt.16, sa.3, ss.13-17, 2014 (Scopus)
Objective: The aim of this study was to evaluate the efficiency and effectiveness of the sedation practice, recovery time, and adverse event profile and total propofol consumption combined propofol infusion plus bolus propofol with different doses of ketamine -propofol combinations for infants and children sedation undergoing ambulatory magnetic resonance imaging Methods: After obtaining approval from the University Ethics Committee, This double-blind, randomized trial enrolled American Society of Anesthesiology (ASA) Class I-III patients, aged 1 month to 12 years requiring MRI under deep sedation. One hundred and forty two patients were included in the study and were divided into 4 groups, prospectively. Premedication consisted of intranasal midazolam 0.5 mg/ kg over six month children. Group I received 1 mg/kg propofol intravenously (IV), bolus followed by a 100 μq/kg/min infusion. Group II, III, IV received IV ketamine bolus of 0.5mg/ kg, 1mg/kg and 1.5mg/kg respectively and then patients received an infusion of a solution containing propofol 100 μq/kg/min augmented with additional propofol boluses as needed. Blood pressure, heart rate, Ramsey sedation scores, oxygen saturation and end-tidal CO2 levels were recorded once every five minutes. Duration of the procedure, total amount of propofol used, time until Aldrete scores reached 9 and additional propofol doses needed were also recorded, as were complications like agitation, desaturation, bradycardia and hypotension Results: There were no differences between the demographic properties of the groups. Twenty- five, 65, 70 and 75th minute heart rates were higher in ketamine groups when compared to Group 1, the difference was significant (p<0.05). Systolic blood pressure levels at 5, 10, 15, 25, 30 and 35th minute were lower in group I. There were no statistically significant differences between diastolic blood pressures, end tidal carbondioxide levels, saturation levels and complications between the groups. More additional propofol needs and longer recovery duration were recorded in group I compared with Group IV. Conclusion: We have found that 1.5mg/kg bolus ketamine doses added to propofol infusion resulted in lower additional propofol doses and shorter recovery times and is a good option in sedation of children during MRI.