Successful surgical treatment of Nicolau's syndrome combined with intravenous iloprost

Gormus N., Tanyeli O., Senaran H., Duman A., Gormus Z. I. S., Durgut K.

VASA-JOURNAL OF VASCULAR DISEASES, vol.38, no.4, pp.378-381, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 4
  • Publication Date: 2009
  • Doi Number: 10.1024/0301-1526.38.4.378
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.378-381
  • Keywords: Fasciotomy, Iloprost, Nicolau's syndrome, penicilline, BENZATHINE PENICILLIN, PROSTACYCLIN ANALOG, CHILDREN
  • Bezmialem Vakıf University Affiliated: No


A 4 year-old boy was admitted to our clinic with symptoms of pain and ecchymosis in his right leg and foot after injection of benzathine penicilline. There was a localized gangrenous area at the femoral injection site. Doppler ultrasonography showed no arterial flow in the femoral artery and clear evidence of acute thrombosis of the superficial femoral and popliteal veins. Femoral arterial and venous thrombectomy and fasciotomy were performed immediately. After surgery the boy was treated by Iloprost infusion and enoxaparine. One week later necrotic changes had regressed, fasciotomies were closed and only the distal phalanx of the third toe needed amputation. Early surgical intervention and standard management combined with Iloprost infusion may help in healing the lesions by increasing extremity perfusion and may prevent extremity loss.