Terpenoids, essential oil composition and fatty acids profile, and biological activities of Anatolian Salvia fruticosa Mill.

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Topcu G., Ozturk M., Kusman T., BARLA DEMIRKOZ A. A., Kolak U., Ulubelen A.

TURKISH JOURNAL OF CHEMISTRY, vol.37, no.4, pp.619-632, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 4
  • Publication Date: 2013
  • Doi Number: 10.3906/kim-1303-25
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.619-632
  • Keywords: Lamiaceae, Salvia fruticosa, secondary metabolites, abietane diterpenoids, triterpenoids, essential oil, fatty oil, antioxidant, anticholinesterase, ROSMARINUS-OFFICINALIS, FAMILY LABIATAE, LAURUS-NOBILIS, CARNOSIC ACID, TRILOBA L., CONSTITUENTS, ANTIOXIDANT, ANTICHOLINESTERASE, DITERPENOIDS, LACTONE
  • Bezmialem Vakıf University Affiliated: Yes


The hexane and dichloromethane extracts, obtained by re-extraction of the methanol extract of Salvia fruticosa Mill., afforded 7 diterpenoids (carnosol, carnosic acid, carnosic acid 12-methyl ether, rosmadial, isorosmanol, ferruginol, and manool), 4 triterpenoids (alpha-amyryltetracosanoate, oleanolic acid, ursolic acid, and erythrodiol), a steroid (3-acetylsitosterol), and a flavone (salvigenin). The galls (apples) of the collected plant were separately extracted with hexane to afford fatty acids composed mainly of oleic acid (29%), palmitoleic acid (29%), and stearic acid (23.20%), which exhibited high anticholinesterase activity, particularly against BChE. The essential oil, obtained from the aerial parts of the plant, exhibited high AChE inhibitory activity, consisting of mainly 1,8-cineol (58.89%). The antioxidant activity according to 6 complementary tests and anticholinesterase potential of the methanol extracts and triterpenoids alpha-amyryltetracosanoate, oleanolic acid, ursolic acid, and sitosterol acetate were also investigated, and methanol extract exhibited the highest antioxidant and anticholinesterase activity, surpassing the other tested extracts and pure compounds.