Terpenoids, essential oil composition and fatty acids profile, and biological activities of Anatolian Salvia fruticosa Mill.

Creative Commons License

Topcu G., Ozturk M., Kusman T., BARLA DEMIRKOZ A. A., Kolak U., Ulubelen A.

TURKISH JOURNAL OF CHEMISTRY, vol.37, no.4, pp.619-632, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 4
  • Publication Date: 2013
  • Doi Number: 10.3906/kim-1303-25
  • Journal Name: TURKISH JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.619-632
  • Keywords: Lamiaceae, Salvia fruticosa, secondary metabolites, abietane diterpenoids, triterpenoids, essential oil, fatty oil, antioxidant, anticholinesterase, ROSMARINUS-OFFICINALIS, FAMILY LABIATAE, LAURUS-NOBILIS, CARNOSIC ACID, TRILOBA L., CONSTITUENTS, ANTIOXIDANT, ANTICHOLINESTERASE, DITERPENOIDS, LACTONE
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

The hexane and dichloromethane extracts, obtained by re-extraction of the methanol extract of Salvia fruticosa Mill., afforded 7 diterpenoids (carnosol, carnosic acid, carnosic acid 12-methyl ether, rosmadial, isorosmanol, ferruginol, and manool), 4 triterpenoids (alpha-amyryltetracosanoate, oleanolic acid, ursolic acid, and erythrodiol), a steroid (3-acetylsitosterol), and a flavone (salvigenin). The galls (apples) of the collected plant were separately extracted with hexane to afford fatty acids composed mainly of oleic acid (29%), palmitoleic acid (29%), and stearic acid (23.20%), which exhibited high anticholinesterase activity, particularly against BChE. The essential oil, obtained from the aerial parts of the plant, exhibited high AChE inhibitory activity, consisting of mainly 1,8-cineol (58.89%). The antioxidant activity according to 6 complementary tests and anticholinesterase potential of the methanol extracts and triterpenoids alpha-amyryltetracosanoate, oleanolic acid, ursolic acid, and sitosterol acetate were also investigated, and methanol extract exhibited the highest antioxidant and anticholinesterase activity, surpassing the other tested extracts and pure compounds.