DNA damaging activities of methanol extract of Ajuga postii and iridoid glucoside reptoside


GOREN A. C. , ZHOU B., Topcu G. , KOKDIL G., KINGSTON D.

NATURAL PRODUCT RESEARCH, cilt.19, ss.457-460, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 19 Konu: 5
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1080/14786410412331272095
  • Dergi Adı: NATURAL PRODUCT RESEARCH
  • Sayfa Sayıları: ss.457-460

Özet

An iridoid glucoside reptoside ( 1) has been isolated as a DNA damaging active agent by bioassay-guided fractionation of the methanol extract of Ajuga postii. Furthermore, from the acetone extract of A. postii two known triterpenic compounds ursolic acid, alpha-amyrin and two steroidal compounds ( 24S)-24-ethylcholesta-5,25-dien-3 beta-ol and beta-sitosterol were isolated. Their structures were elucidated based on 1D and 2D NMR techniques and mass data.