Matrix metalloprotease-9 expresssion in meningioma: Correlation with growth fraction and role of gender. A pilot immunohistochemical study

---

Copy For Citation

ÖZEK E., Ozcan D., Celik S. E., Iplikcioglu A. C.

CLINICAL NEUROLOGY AND NEUROSURGERY, vol.172, pp.169-173, 2018 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 172
• Publication Date: 2018
• Doi Number: 10.1016/j.clineuro.2018.07.002
• Journal Name: CLINICAL NEUROLOGY AND NEUROSURGERY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.169-173
• Bezmialem Vakıf University Affiliated: Yes

Abstract

Objective: Matrix metalloproteases (MMPs), particularly MMP2 and MMP9 increase tumor invasion and edema in meningiomas. Although lesser recognized, MMPs may also enhance cell growth via liberating growth factors or via cleaving inactive growth factors into active isoforms. However, there exist very few studies, which investigated correlation of MMPs with growth fraction in meningiomas. Meningiomas are seen more frequently in women and their growth accelarate during pregnancy. However, no study examined whether MMP-expressions in meningioma differ with gender.