Matrix metalloprotease-9 expresssion in meningioma: Correlation with growth fraction and role of gender. A pilot immunohistochemical study


ÖZEK E. , Ozcan D., Celik S. E. , Iplikcioglu A. C.

CLINICAL NEUROLOGY AND NEUROSURGERY, cilt.172, ss.169-173, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 172
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.clineuro.2018.07.002
  • Dergi Adı: CLINICAL NEUROLOGY AND NEUROSURGERY
  • Sayfa Sayıları: ss.169-173

Özet

Objective: Matrix metalloproteases (MMPs), particularly MMP2 and MMP9 increase tumor invasion and edema in meningiomas. Although lesser recognized, MMPs may also enhance cell growth via liberating growth factors or via cleaving inactive growth factors into active isoforms. However, there exist very few studies, which investigated correlation of MMPs with growth fraction in meningiomas. Meningiomas are seen more frequently in women and their growth accelarate during pregnancy. However, no study examined whether MMP-expressions in meningioma differ with gender.