Research Information System
5th International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2022), Ankara, Turkey, 23 - 25 November 2022, pp.331
Arthritis is defined as a degenerative joint disease that has different forms, primarily rheumatoid arthritis, osteoarthritis, gouty arthritis, and involves most of the cartilage and surrounding tissues. It is an autoimmune disease characterized by painful joints, joint stiffness and limitation of movement, and intense inflammatory responses. Factors such as cigarette consumption, infectious agents, environmental pollution and chronic stress have been found to trigger intense inflammatory responses in arthritis. Apart from these factors, the role of nutrition has been suggested by increasing evidence recently. In some studies, fruit, vegetable or meat consuming has been associated with diet and disease status, but no definitive conclusion has been reached. Arthritis has been observed that the prevalence is lower in those who eat the Mediterranean diet. It is thought that some other diet types also have a relieving effect on the symptoms of the disease. Vegetarian diet, gluten-free diet, Mediterranean diet, elimination diet or intermittent fasting diet are some of these diets. Genetics is also thought to have an effect on arthritis. Genetic and environmental factors are thought to play an important role in the pathophysiology and occurrence of the disease. The data identify diet as an environmental factor in the development of arthritis, with diet increasing the inflammatory response in genetically predisposed individuals. Recently, it has been suggested that obesity, diabetes and metabolic syndrome are important risk factors for the development of arthritis. Obesity is a modifiable risk factor for arthritis. Arthritis treatment is limited. In general, there is a treatment that reduces the symptoms related to the patient's symptoms or if there is a serious dysfunction in the joint, there are treatment options with total joint replacement. There is a call for a change in a system that focuses on teaching patients with arthritis to self-manage their condition based on their symptoms. Increased inflammation and impaired immune system regulation, which are among the basic pathophysiological mechanisms in the formation of arthritis, play an important role in the development of comorbidities. It is known that many comorbidities accompany arthritis. Some of these comorbidities are cardiovascular diseases, malignancies, infections, and osteoporosis. In addition, comorbidities can significantly increase the risk of mortality. In this study, the mechanisms and nutritional approaches in the formation of arthritis will be examined in the light of the current literature.
Keywords: Arthritis, Mediterranean diet, Elimination diet, Obesity, Inflammatory response