Comparison of Ozon and Photobiomodulation Therapieson Mental Nerve Injury in Rats

Yücesoy T. , Kütük N. , Günay Canpolat D., Alkan A.

AÇBİD 10th International Congress-2016, Antalya, Türkiye, 11 - 15 Mayıs 2016

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Antalya
  • Basıldığı Ülke: Türkiye


Neurosensorial disturbances (ND) can occur due to the injury, dysfunction and innervation changes of peripheral or central nervous system, and associated with altered sensation and chronic pain. Wisdom teeth surgeries, loca anesthesia injections, orthognatic surgery, distraction osteogenesis, implant surgery, and endodontic treatment can cause ND. Proper treatment methods are stil being investigated for the treatment of this undesirable complication. Ozone is biocompatible with oral epitelial cells, gingival fibroblasts and periodontal cells, and ozone therapy (OT) has succesfull outcomes in oral and maxillofacial surgery and implantology. Photobiomodulation (PBM) stimulates proliferation and differantiation of fibroblasts, osteoblasts, and chondroblasts. PBM is a treatment method that has effective outcomes on nerve repair and bone regeneration. In the present study, the effects of ozone and PBM therapies on mental nerve injury were evaluated. Mental nerves of 27 rats were partly suturated and allocated into three groups. Group 1 recevied no treatment, whereas OT and PBM therapies were administered in Group 2 and Group 3, respectively. Number of fascicules after nerve branching and schwann cell counting before and after nerve injury have been evaluated histologically. A better healing pattern was observed in the treatment groups. The number of Schwann cells were significantly greater in OT and PBM groups. Oral and maxillofacial surgeons must be familiar with the differential diagnosis, prevention, and management of neurosensory disturbances. This study provides insights into the management of neurosensory disturbances related to mental nerve injury by using OT and PBM. Our study clearly suggest that OT and PBM are promising novel methods in the treatment of mental nerve injury