Increased DNA damage in patients with complete hydatidiform mole

Harma M., Harma M., Kocyigit A. , EREL O.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, cilt.583, sa.1, ss.49-54, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 583 Konu: 1
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.mrgentox.2005.01.014
  • Sayfa Sayıları: ss.49-54


The pathologic mechanisms underlying the gestational trophoblastic diseases are largely unexplored, but are thought to involve oxidative damage to the maternal vasculature and also to the placenta. In this study we have assessed the plasma levels of total antioxidant response (TAR) and the levels of endogenous DNA damage - determined by the comet assay - in peripheral blood lymphocytes from 13 women with complete hydatidiform mole (CHM) and compared these with those of 12 healthy pregnant controls and 10 healthy non-pregnant controls. Significantly lower mean levels of plasma TAR were found in patients with CHM compared with healthy pregnant controls (1.08 +/- 0.29 versus 1.17 +/- 0.14 mmol Trolox Eq/L, p < 0.05) and with healthy non-pregnant controls (1.08 +/- 0.29 versus 1.38 +/- 0.12 mmol Trolox Eq/L, p < 0.05). Significantly higher mean levels of endogenous DNA damage were observed in patients with CHM than in healthy pregnant controls (234.5 +/- 50.74 versus 125.7 +/- 45.4 AU, p < 0.05) or in healthy non-pregnant controls (234.5 +/- 50.74 versus 104.0 +/- 49.6 AU, p < 0.05).