Serum Electrolyte Values and Blood Oxidative Stress Parameters in Patients with Focal and Generalized Epilepsy

Sarı G., KILIÇ A., USLU F., SELEK Ş., ÜSTÜNOVA S., MERAL İ.

Eastern Journal of Medicine, cilt.28, sa.1, ss.94-98, 2023 (Scopus, TRDizin) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 1
  • Basım Tarihi: 2023
  • Doi Numarası: 10.5505/ejm.2023.93195
  • Dergi Adı: Eastern Journal of Medicine
  • Derginin Tarandığı İndeksler: Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.94-98
  • Anahtar Kelimeler: Focal epilepsy, generalized epilepsy, minerals, oxidative stress, trace elements
  • Bezmiâlem Vakıf Üniversitesi Adresli: Evet

Özet

Because epilepsy pathogenesis is affected by serum minerals and antioxidant enzymes, this study was designed to evaluate whether there was a relationship among electrolytes (Na, Ca, K, Cl, P, Mg), trace elements (Fe, Zn, Cu) and oxidative stress in patients with generalized or focal epilepsy. Twenty healthy individuals (control group), and 20 focal and 20 generalized epilepsy patients (patient groups) were included in the study. Control and patient groups were matched with age (30-40 years old), body mass index (25-28) and sex (10 males and 10 females). Serum Na, Ca, K, Cl, P, Mg and Fe levels were analyzed in an autoanalyzer, serum Zn and Cu were analyzed in a mass spectrophotometer, total antioxidant status, total oxidant status and myeloperoxidase levels were measured spectrophotometrically. The oxidative stress index increased (p<0.001) and the serum Na levels decreased (p<0.001) in focal epilepsy patients compared to the controls. It has been concluded these changes may make focal epilepsy patients more susceptible to seizures than generalized epilepsy patients.