The relation of urinary bisphenol A with kisspeptin in girls diagnosed with central precocious puberty and premature thelarche.

Ozgen I. T., Torun E., Bayraktar-Tanyeri B., Durmaz E., Kilic E., Cesur Y.

Journal of pediatric endocrinology & metabolism : JPEM, vol.29, no.3, pp.337-41, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.1515/jpem-2015-0235
  • Journal Name: Journal of pediatric endocrinology & metabolism : JPEM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.337-41
  • Keywords: bisphenol A, kisspeptin, precocious puberty, premature thelarche, GONADOTROPIN-RELEASING-HORMONE, ENDOCRINE-DISRUPTING CHEMICALS, EXPOSURE, RECEPTOR, MECHANISMS, MUTATION, INFANTS, NEURONS, GROWTH
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Background: Bisphenol A (BPA) is known as an endocrine disruptor and it is supposed to have a role on the development of central precocious puberty (CPP). Kisspeptin, a hypothalamic peptide, is a neuromodulator of gonadotropin releasing hormone and it has an important role on regulation of the onset of puberty. The BPA levels in girls with CPP and premature thelarche (PT) and its relation with kisspeptin levels were investigated.