Association Between Factor V Leiden Gene Mutation and Systemic Involvement in Behcet's Disease

CEBECI F., TOPCU E., Onsun N., Su Ö. S.

TURKDERM-ARCHIVES OF THE TURKISH DERMATOLOGY AND VENEROLOGY, vol.43, no.1, pp.21-24, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 1
  • Publication Date: 2009
  • Journal Name: TURKDERM-ARCHIVES OF THE TURKISH DERMATOLOGY AND VENEROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.21-24
  • Bezmialem Vakıf University Affiliated: Yes

Abstract

Background and Design: Behcet's disease is a chronic, multisystem inflammatory disease of unknown origin characterized mainly by recurrent oral aphthous ulceration, genital ulceration, skin lesions and uveitis. Thrombophilic defects, such as factor V Leiden (FVL) gene mutation may play a role in the pathogenesis of thrombosis in Behcet's disease (BD). Recently, an association of FVL mutation with thrombosis and ocular involvement in BID has been reported. The object of this present study was to investigate an association between systemic involvement and the presence of the FVL gene mutation in BID patients.