BRADYKININ RECEPTORS IN INTESTINAL SMOOTH MUSCLES AND THEIR POSTRECEPTOR EVENTS RELATED TO CALCIUM


OZTURK Y., ALTAN V. M. , YILDIZOGLUARI N., ALTINKURT O.

MEDIATORS OF INFLAMMATION, vol.2, no.4, pp.309-315, 1993 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 2 Issue: 4
  • Publication Date: 1993
  • Doi Number: 10.1155/s0962935193000432
  • Title of Journal : MEDIATORS OF INFLAMMATION
  • Page Numbers: pp.309-315

Abstract

THE effects of trifluoperazine and verapamil on bradykinin- and des-Arg9-bradykinin induced responses of isolated rat duodenum and guinea-pig ileum were investigated to elucidate post-bradykinin receptor events. Verapamil and trifluoperazine inhibited bradykinin induced relaxations and contractions and des-Arg9-bradykinin induced contractions in rat duodenum. Bradykinin induced contractions of ileum were also inhibited by trifluoperazine and verapamil. Since non-competitive affinity constants of trifluoperazine and verapamil for the relaxant responses to bradykinin in duodenum and for the contractile responses to bradykinin in ileum are different, post-bradykinin receptor events related to calcium may be different in ileum and duodenum. In addition, affinity constants of bradykinin in guinea-pig ileum and rat duodenum are also disparate suggesting the presence of different types of bradykinin B2 receptors in these two organs.