Bioassay-guided evaluation of anti-inflammatory and antinociceptive activities of pistachio, Pistacia vera L.

Orhan I., Kupeli E., Aslan M., Kartal M., Yesilada E.

JOURNAL OF ETHNOPHARMACOLOGY, vol.105, pp.235-240, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 105
  • Publication Date: 2006
  • Doi Number: 10.1016/j.jep.2005.10.023
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.235-240
  • Keywords: anti-inflammatory activity, antinociceptive activity, Pistacia vera, anacardiaceae, pistachio, oleoresin, GC-MS, alpha-pinene, ESSENTIAL OILS, CHEMICAL-COMPOSITION, MASTIC GUM, BLED RESIN, MONOTERPENES, COMPONENTS, FRACTION, ACID, RATS
  • Bezmialem Vakıf University Affiliated: No


The ethanolic and aqueous extracts prepared from different parts of Pistacia vera L. (Anacardiaceae) as well as its oleoresin were evaluated for their in vivo anti-inflammatory and antinociceptive activities. Among the extracts screened, only the oleoresin was shown to possess a marked anti-inflammatory activity against carrageenan-induced hind paw edema model in mice without inducing any gastric damage at both 250 and 500 mg/kg doses whereas the rest of the extracts were totally inactive. While the oleoresin was found to display significant antinociceptive activity at 500 mg/kg dose, the ethanolic and aqueous extracts belonging to fruit, leaf, branch and peduncle of Pistacia vera did not exhibit any noticeable antinociception in p-benzoquinone-induced abdominal contractions in mice. Fractionation of the oleoresin indicated the n-hexane fraction to be active, which further led to recognition of some monoterpenes, mainly a-pinene (77.5%) by capillary gas chromatography-triass spectrometry (GC-MS) as well as the oleoresin itself. alpha-Pinene was also assessed for its antinociceptive and anti-inflammatory activities in the same manner and exerted a moderate anti-inflammatory effect at 500 mg/kg dose. (c) 2005 Elsevier Ireland Ltd. All rights reserved.